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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Interaction of DNA with a novel photoactive platinum diimine complex
1Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi, 030006, China. zgzhang@sxu.edu.cn
Abstract:
Interaction of DNA with a novel photoactive platinum diimine compound has been studied by electronic absorption spectra, fluorescence spectra and viscosity measurements. The red light-induced DNA cleavage activity of the platinum compound has also been studied by agarose gel electrophoresis. The results suggest that the platinum compound may interact with DNA by intercalation mode. When irradiated with red light, the platinum compound can generate singlet oxygen, resulting in cleavage of DNA.

