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Updated: Jun 29, 2026
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Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
Published on: November 14, 2025
The autonomic nervous system and ischemic stroke: a reciprocal interdependence
Giuseppe Micieli1, Anna Cavallini
1Neurology and Stroke Unit, IRCCS Istituto Clinico Humanitas, Via Manzoni, 56, 20089, Rozzano, MI, Italy. giuseppe.micieli@humanitas.it
Summary
Autonomic nervous system (ANS) dysfunction is common after stroke, but its role in causing stroke is unclear. This review explores the link between ANS disorders and stroke, suggesting new diagnostic and therapeutic strategies.
Area of Science:
- Neurology
- Cardiology
- Autonomic Neuroscience
Background:
- Autonomic nervous system (ANS) dysfunction frequently occurs post-stroke, with patterns related to lesion location and extent.
- The causal role of ANS disorders in stroke development remains largely unknown.
- Risk factors for atherothrombotic stroke are often linked to ANS dysfunction.
Purpose of the Study:
- To investigate the potential relationship between autonomic nervous system disorders and stroke.
- To explore the hypothesis of a reciprocal interdependence between ANS and stroke.
- To propose novel diagnostic and therapeutic approaches based on pathogenetic mechanisms.
Main Methods:
- Literature review of studies on ANS dysfunction and stroke.
- Analysis of evidence linking ANS dysfunction to myocardial infarction and atherothrombotic stroke.
- Examination of risk factors for stroke associated with ANS alterations.
Main Results:
- Evidence suggests ANS dysfunction may play a role in myocardial infarction and atherothrombotic stroke.
- A strong correlation exists between stroke risk factors and altered ANS functioning.
- A reciprocal relationship between ANS and stroke is plausible.
Conclusions:
- Autonomic nervous system dysfunction may contribute to stroke pathogenesis.
- A bidirectional relationship between ANS and stroke warrants further investigation.
- Understanding this link can inform distinct diagnostic and therapeutic strategies for both conditions.
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