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Moderate mitral regurgitation in patients undergoing CABG--the MoMIC trial

Per Wierup1, Henrik Egeblad, Sten Lyager Nielsen

  • 1Department of Cardiothoracic Surgery, Aarhus University Hospital, Skejby, Aarhus, Denmark. pwi@sks.aaa.dk

Scandinavian Cardiovascular Journal : SCJ
|October 14, 2008
PubMed

Insights

For patients undergoing coronary artery bypass grafting (CABG), the Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial investigates if correcting moderate ischemic mitral regurgitation (IMR) improves survival. Results will guide treatment decisions for this common condition.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Clinical Trials

Background:

  • Moderate ischemic mitral regurgitation (IMR) is linked to poor long-term survival and heart failure hospitalizations.
  • Current practice often omits mitral valve repair in CABG patients with moderate IMR.
  • Lack of robust data necessitates a large-scale trial to inform clinical decision-making.

Purpose of the Study:

  • To determine if mitral valve correction alongside CABG improves outcomes in patients with moderate IMR.
  • To provide evidence-based guidance for managing moderate IMR during CABG surgery.

Main Methods:

  • The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is an international, multi-center study.
  • 550 patients with moderate IMR undergoing CABG will be randomized.
  • Comparison of CABG alone versus CABG plus mitral valve correction.
  • Primary endpoint: composite of mortality and heart failure rehospitalization at five years.

Main Results:

  • Patient enrollment and randomization commenced in February 2008.
  • The study is designed to provide definitive data on the efficacy of mitral valve correction in this population.

Conclusions:

  • Findings will clarify whether mitral valve correction is a superior strategy for moderate IMR in CABG patients.
  • If proven beneficial, the results are expected to influence clinical practice guidelines.
Abstract

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