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Updated: Jun 29, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Published on: December 11, 2017

[Cardiac resynchronization therapy in non-ischemic cardiomyopathy].

S Weretka¹, N Rüb, H J Weig

¹Abteilung Innere Medizin III, Kardiologie, Medizinische Universitätsklinik Tübingen, Otfried-Mueller-Str. 10, 72076 Tübingen. slawomir.weretka@med.uni-tuebingen.de

Deutsche Medizinische Wochenschrift (1946)

|October 14, 2008

Summary

Cardiac resynchronization therapy (CRT) effectively treated advanced heart failure in a patient with non-ischemic cardiomyopathy post-liver transplant. This intervention offered a solution when pharmacologic therapy proved insufficient for managing severe systolic dysfunction.

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Area of Science:

Cardiology
Transplantation Medicine
Infectious Diseases

Background:

Advanced heart failure often requires advanced therapies beyond pharmacologic treatment.
Non-ischemic cardiomyopathy can develop or be exacerbated by various factors, including viral infections and post-transplant complications.
Cardiac resynchronization therapy (CRT) is indicated for specific heart failure patients with systolic dysfunction and conduction delays.

Observation:

A patient with a history of liver transplantation experienced progressive congestive heart failure.
The heart failure was attributed to non-ischemic cardiomyopathy, potentially linked to hepatitis C reactivation post-transplant.
Standard pharmacologic therapy for heart failure yielded an insufficient clinical response.

Findings:

The patient presented with severe systolic dysfunction and a wide QRS complex, meeting criteria for CRT.
Successful treatment with cardiac resynchronization therapy (CRT) was achieved.
CRT significantly improved the patient's heart failure symptoms and condition.

Implications:

This case highlights the potential benefit of CRT in complex heart failure scenarios, including those arising after organ transplantation.
It underscores the importance of considering cardiac complications in post-transplant patients, especially with underlying viral hepatitis.
Cardiac resynchronization therapy (CRT) may be a viable option for non-ischemic cardiomyopathy refractory to medical management.