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Published on: October 14, 2022
Amniotic membrane transplantation: indications and results
E H Yildiz1, A B Nurozler, N Ozkan Aksoy
1Department of Ophthalmology, Ankara Education and Research Hospital, Ankara - Turkey. drelvinyildiz@yahoo.com
European Journal of Ophthalmology
|October 14, 2008
Summary
Amniotic membrane transplantation effectively promotes corneal healing across various conditions. This study found it to be a successful adjunctive method for corneal epithelization in diverse patient groups.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Corneal Surgery
Background:
- Corneal defects and injuries pose significant challenges to maintaining visual integrity.
- Amniotic membrane transplantation (AMT) is a recognized therapeutic option for ocular surface diseases.
- Understanding the specific indications and outcomes of AMT is crucial for clinical practice.
Purpose of the Study:
- To detail the indications for amniotic membrane transplantation (AMT) at our institution.
- To evaluate the clinical results and success rates of AMT in a diverse patient cohort.
- To assess the efficacy of AMT in promoting corneal integrity and epithelialization.
Main Methods:
- A retrospective chart review was conducted for 108 patients who underwent AMT between January 2002 and April 2006.
- Patients were categorized into six diagnostic groups based on their condition prior to transplantation.
- Kaplan-Meier survival analysis was employed to compare the corneal integrity survival rates as a measure of success.
Main Results:
- The study included 108 patients (75 female, 51 male; mean age 55.2 years) undergoing AMT for conditions including corneal perforation, persistent epithelial defects, bullous keratopathy, infectious ulcers, necrotizing keratitis, and caustic injury.
- Amniotic membrane transplantation was performed on eyes with nontraumatic corneal perforation (32), persistent epithelial defect (29), aphakic/pseudophakic bullous keratopathy (18), infectious ulcer (14), necrotizing keratitis (10), and caustic injury (5).
- The mean survival of corneal integrity was statistically similar across all diagnostic groups (p=0.156), indicating consistent efficacy.
Conclusions:
- Amniotic membrane transplantation serves as a valuable adjunctive therapy for promoting corneal epithelialization.
- The procedure demonstrated success in managing a wide spectrum of ocular surface pathologies requiring corneal repair.
- AMT is a viable option for preserving corneal integrity in various challenging clinical scenarios.
