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Updated: Jun 29, 2026

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
09:08

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

How rigid are viruses.

R D Hartschuh1, S P Wargacki, H Xiong

  • 1Department of Polymer Science, University of Akron, Akron, Ohio 44325, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|October 15, 2008
PubMed
Summary
This summary is machine-generated.

Wiseana iridovirus (WIV) exhibits surprisingly high mechanical rigidity (Young's modulus ~7 GPa), primarily due to its DNA core. This study explores WIV

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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Last Updated: Jun 29, 2026

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

Area of Science:

  • Biophysics
  • Materials Science
  • Virology

Background:

  • Viruses are increasingly utilized beyond their pathogenic roles in fields like nanotechnology and gene therapy.
  • While viral structures are known, their mechanical and biophysical properties are under-explored.

Purpose of the Study:

  • To investigate the mechanical rigidity, intervirion coupling, and vibrational properties of Wiseana iridovirus (WIV).
  • To understand the contribution of the viral core to mechanical properties.

Main Methods:

  • Brillouin light scattering was employed to analyze WIV particles.
  • Mechanical modeling was used to interpret the experimental data.

Main Results:

  • Identified phonon modes in viral assemblies and localized modes in individual WIV particles.
  • Determined a Young's modulus of approximately 7 GPa for WIV, indicating significant rigidity.
  • Mechanical modeling revealed that the viral DNA core is the primary determinant of WIV's rigidity.
  • Observed unusual mechanical coupling during WIV self-assembly.

Conclusions:

  • Wiseana iridovirus possesses exceptionally high mechanical rigidity for a biological material, largely attributed to its DNA core.
  • The findings provide novel insights into the biophysical properties of viruses and their potential in materials science applications.
  • The study highlights peculiar mechanical interactions during viral self-assembly.