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Prognostic parameters for recurrence of papillary thyroid microcarcinoma
Tae Yong Kim1, Suck Joon Hong, Jung Min Kim
1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. tykim@amc.seoul.kr
BMC Cancer
|October 15, 2008
Summary
Papillary thyroid microcarcinoma (PTMC) recurrence is not rare and depends on prognostic factors. Gender and lateral neck node metastasis are key predictors, influencing treatment decisions for PTMC.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Papillary thyroid microcarcinoma (PTMC) is defined as papillary thyroid carcinoma ≤1.0 cm.
- Independent prognostic factors for PTMC recurrence remain unclear.
Purpose of the Study:
- To identify clinicopathological parameters predicting PTMC recurrence.
- To inform surgical extent based on prognostic factors.
Main Methods:
- Retrospective analysis of 307 patients with PTMC.
- Evaluation of clinicopathological parameters and recurrence rates.
Main Results:
- 14% of 293 eligible patients experienced recurrence over a median 65-month follow-up.
- Gender and lateral cervical node metastasis were significant predictors of recurrence in total/near-total thyroidectomy patients.
- No significant prognostic factor was identified for recurrence in hemi-/subtotal thyroidectomy patients.
Conclusions:
- PTMC exhibits diverse disease extent and is not always indolent.
- Surgical extent for PTMC should consider prognostic parameters like gender and lateral neck node metastasis.
