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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 29, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

[Tumor proteomics: the past, present and future].

Xiao-En Xu1, Ying-Hua Jiang, Qian Shi

  • 1College of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.

AI Zheng = Aizheng = Chinese Journal of Cancer
|October 15, 2008
PubMed
Summary

Tumor proteomics utilizes advanced techniques to identify cancer biomarkers for early detection, diagnosis, and treatment. This research reviews methods and achievements, aiming to improve clinical applications and understand cancer mechanisms.

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Industrialized, Artificial Intelligence-guided Laser Microdissection for Microscaled Proteomic Analysis of the Tumor Microenvironment
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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Context:

  • Proteomics techniques are increasingly applied to tumor biology research.
  • Tumor proteomics aims to discover biomarkers for various clinical applications.

Purpose:

  • To screen biomarkers for tumor detection, diagnosis, prognosis, and treatment.
  • To review methods and achievements in tumor proteomics studies.
  • To elucidate underlying mechanisms of tumorigenesis.

Summary:

  • This review covers tumor proteomics, detailing techniques like 2-DE, SILAC, and MALDI.
  • It discusses three stages: expression, post-translation modification, and activity-based proteomics.
  • Achievements in major tumor types are highlighted, alongside challenges in clinical application.

Impact:

  • Advances in tumor proteomics can lead to improved cancer diagnostics and therapeutics.
  • Understanding tumorigenesis mechanisms may offer new strategies to combat cancer.
  • The field aims to translate proteomic discoveries into tangible clinical benefits.