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The impact of single substitutions on multiple sequence alignments.

Steffen Klaere1, Tanja Gesell, Arndt von Haeseler

  • 1Center for Integrative Bioinformatics Vienna, University of Vienna, Medical University Vienna, Veterinary University Vienna, Max F. Perutz Laboratories, Dr Bohrgasse 9, 1030 Wien, Austria. steffen.klaere@univie.ac.at

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|October 15, 2008
PubMed
Summary

We present a novel two-step model for sequence evolution, using scaled branch lengths and Poisson-distributed substitutions. This approach yields analytical formulas for substitution probabilities in phylogenetic analysis.

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