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Glatiramer acetate-associated, CD30+, primary, cutaneous, anaplastic large-cell lymphoma
Monica M Madray1, John F Greene, David F Butler
1Department of Dermatology, Scott and White Memorial Hospital, 2401 S 31st St, Temple, TX 76508, USA.
Objective:
To report the association of the development of a primary, cutaneous, anaplastic large-cell lymphoma after initiation of glatiramer acetate treatment of a patient with relapsing-remitting multiple sclerosis.
Design:
Case report.
Setting:
Dermatology outpatient clinic. Patient A 33-year-old white woman developed an erythematous nodule on her leg 4 months after starting treatment with glatiramer acetate. Biopsy showed primary, cutaneous, anaplastic large-cell lymphoma. Further evaluation showed no systemic involvement. Intervention Radiation therapy induced a complete remission.
Conclusions:
Several T-cell-mediated skin conditions have been associated with the use of glatiramer acetate, such as pseudolymphoma, drug eruptions, and erythema nodosum. We report the association of a T-cell malignancy with the use of glatiramer acetate.