Related Experiment Video
Updated: Jun 29, 2026
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
Transient bevacizumab (avastin)-induced alterations in rat eyes
María Sancho-Tello1, Siv Johnsen-Soriano, María Muriach
1Fundación Oftalmológica del Mediterráneo, Universidad CEU-Cardenal Herrera, Valencia, España.
Aims:
To study the histopathological, biochemical and functional effects of intravitreal bevacizumab on the rat eye, with special emphasis on its immediate pro-inflammatory features eventually associated with cellular oxidative burden.
Methods:
Histopathological evaluation was performed 24 h, 1 and 4 weeks after bevacizumab (75 microg/rat eye) or saline intravitreal injection, as well as biochemical analysis of oxidative stress-related markers and electroretinograms.
Results:
Bevacizumab induces a transient inflammatory reaction together with a modification of the b-wave amplitude and latency of the electroretinogram. No changes were observed in any of the oxidative stress markers studied at any time after injection.
Conclusion:
Intravitreal bevacizumab injection per se generates an immediate, transient and mild inflammation of the rat eye, which is not associated with oxidative stress in ocular tissues.
