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Type II Diabetes II: Pathophysiology

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Type I Diabetes II: Pathophysiology

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Diabetes Mellitus: Type 2 and Gestational

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Complications of Diabetes Mellitus

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Updated: Jun 29, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Diabetes and osteoporosis.

Alois Saller¹, Stefania Maggi, Giovanna Romanato

¹Aging Section, CNR Institute of Neuroscience, 35128 Padova, Italy. alois.saller@unipd.it

Aging Clinical and Experimental Research

|October 15, 2008

Summary

Diabetes care must include bone health assessment. Patients with type 1 diabetes have lower bone mineral density (BMD) and higher fracture risk, while type 2 diabetes patients with complications also face increased fracture risks, highlighting the need for osteoporosis evaluation.

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Last Updated: Jun 29, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Area of Science:

Endocrinology
Gerontology
Orthopedics

Background:

Improved medical care has increased life expectancy for people with diabetes, elevating the significance of osteoporosis.
Diabetes itself compromises bone health, adding to age-related osteoporosis risks.
Pathogenetic complexity in diabetes mellitus has led to conflicting results in bone involvement studies.

Purpose of the Study:

To review the occurrence of osteoporosis in patients with type 1 and type 2 diabetes.
To examine the impact of diabetes on bone health and fracture risk.
To highlight the importance of bone health assessment in diabetes care.

Main Methods:

Literature review examining studies on bone involvement in diabetes mellitus.
Analysis of existing evidence on bone mineral density (BMD) and fracture risk in diabetes.
Exploration of factors influencing fracture probability, including sarcopenia.

Main Results:

Patients with type 1 diabetes exhibit lower BMD and increased fracture risk.
Emerging evidence suggests type 2 diabetes patients with complications also have a higher risk of osteoporotic fractures.
Despite higher BMD in type 2 compared to type 1 diabetes, complications increase fracture risk.

Conclusions:

Bone health assessment is crucial for all patients with diabetes.
Sarcopenia is a key determinant of bone fragility and fracture risk in diabetic patients.
Understanding the distinct bone health profiles in type 1 and type 2 diabetes is essential for effective patient management.