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Updated: Jun 29, 2026
Measuring Influenza Neutralizing Antibody Responses to A(H3N2) Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells
Published on: November 22, 2017
[Prevalence of neutralizing antibodies to dengue virus serotypes in university students from Tabasco, Mexico]
Gilma Guadalupe Sánchez-Burgos1, Miguel Angel López-Alvarado, Deyanira Castañeda-Desales
1Unidad de Investigación Médica, Yucatán.
Objective:
Determine the seroprevalence of neutralizing antibodies to dengue virus in students from the state university of Tabasco, Mexico.
Material And Methods:
A transversal study was conducted of serum collected from students between September and November, 2005. The sera were screened for anti-dengue IgG and those that had evidence of dengue antibodies were analyzed by a plaque reduction neutralization test.
Results:
Prevalence of anti-dengue IgG was 9.1%. The frequency of neutralizing antibodies was 100% for DENV-2, 68% for DENV-4, 20% for DENV-1, and 4 % for DENV-3.
Conclusions:
We found that in this population, DENV-2 circulates more than DENV-3 despite the fact that DENV-3 is more frequently isolated. Unexpectedly, neutralizing antibodies against DENV-4 were frequently found even though this serotype is almost extinct; thus, it is probable that cross-immunity could suppress DEN-4 transmission, as has been suggested.
