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[Seroprevalence of celiac disease at a general pediatric outpatient clinic]
Kátia Galeão Brandt1, Giselia Alves Pontes da Silva
1Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Insights
Seroprevalence of celiac disease is high in children and adolescents. Routine serological screening is recommended for early diagnosis and prevention of complications.
Area of Science:
- Pediatric gastroenterology
- Immunology
- Epidemiology
Context:
- Celiac disease affects children and adults, necessitating early diagnosis to prevent severe complications.
- Limited seroprevalence data exists for this condition in certain regions.
Purpose:
- To ascertain the seroprevalence of celiac disease in pediatric outpatients.
- Utilized human tissue anti-endomysial and anti-transglutaminase antibodies for diagnosis.
Summary:
- A descriptive cross-sectional study was conducted.
- Initial screening used guinea pig anti-transglutaminase antibodies, followed by human tissue antibody assays in positive cases.
- The seroprevalence, based on three positive tests, was 1.9% (16/831), with 71% concordance between human anti-transglutaminase and anti-endomysial antibodies.
Impact:
- The study reveals a high seroprevalence of celiac disease in the studied pediatric population.
- Recommends routine serological screening for children and adolescents presenting with compatible symptoms and those at high risk.
Background:
Celiac disease is a common problem affecting children and adults, for which early diagnosis and treatment prevent complications and deaths. Seroprevalence studies in our environment are still scarce.
Aims:
To determine the seroprevalence of celiac disease by using human tissue antiendomysial and anti-transglutaminase antibodies, among children and adolescents who were attended at a general pediatric outpatient clinic.
Methods:
This was a seroprevalence study of descriptive cross-sectional design. First, assays for guinea pig tissue anti-transglutaminase antibodies were performed. Subsequently, in the positive cases, assays for human tissue antiendomysial and anti-transglutaminase antibodies were performed.
Results:
The seroprevalence of celiac disease by means of anti-guinea pig tissue anti-transglutaminase antibodies was 5% (42/831; 95% CI: 3.76%-6.90%). Considering three positive tests, the seroprevalence was 1.9% (16/831; 95% CI: 1.83%-1.97%). The concordance of human anti-transglutaminase with antiendomysial was 71%.
Conclusions:
The seroprevalence of celiac disease was high. Serological screening for celiac disease among children and adolescents who present signs and/or symptoms compatible with celiac disease should be performed routinely, as well as in groups already known to be at risk, given the high seroprevalence of celiac disease observed in our environment.
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