Postoperative lomefloxacin 0.3% prophylaxis in strabismus surgery

Area of Science:

• Ophthalmology
• Infectious Diseases
• Pharmacology

Background:

• Strabismus surgery necessitates effective postoperative care to prevent complications.
• Antibiotic eye drops are crucial for managing infection and inflammation post-surgery.

Purpose of the Study:

• To compare the efficacy of topical lomefloxacin 0.3% with chloramphenicol 0.2% plus polymyxin B in treating patients after strabismus surgery.
• To evaluate the impact on clinical signs of local cellulitis and conjunctival culture findings.

Main Methods:

• A randomized controlled trial involving 79 patients undergoing strabismus surgery.
• Patients received either lomefloxacin or chloramphenicol/polymyxin B, alongside dexamethasone and diclophenac.
• Clinical signs and conjunctival cultures were monitored postoperatively.

Main Results:

• Both treatment groups showed significant reductions in chemosis and hyperemia.
• Cumulative clinical sign scores decreased to zero in both groups by day 28.
• Bacterial culture positivity rates decreased in both lomefloxacin and chloramphenicol groups.

Conclusions:

• Topical lomefloxacin is a viable alternative to chloramphenicol for postoperative strabismus surgery care.
• Lomefloxacin effectively controls pain, infection, discharge, chemosis, hyperemia, and conjunctival hemorrhage.
• Both agents demonstrated comparable efficacy in reducing key postoperative inflammatory markers.