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Updated: Jun 29, 2026
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Postradiotherapy neck dissection for head and neck squamous cell carcinoma: pattern of pathologic residual carcinoma
Miriam N Lango1, Genevieve A Andrews, Sidrah Ahmad
1Division of Head and Neck Cancer, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. Miriam.Lango@fccc.edu
Background:
For patients with head and neck cancer who were treated using primary radiotherapeutic approaches, the pattern of pathologic residual carcinoma in the neck dissection specimen and its effect on clinical outcome remains unknown.
Methods:
Medical records of 65 patients who underwent 71 neck dissections a median 7 weeks after radiotherapy were reviewed. Median follow-up was 33 months.
Results:
Residual cancer, identified in 28 patients (43%), diminished locoregional control (p = .018), recurrence-free (p = .018), and overall survival (p = .02). Thirteen patients (20%) had 2 or more pathologically involved lymph nodes. Nine (13%) involved level V. Four (6%) had pathologic involvement of nodal levels not clinically involved by cancer before treatment. In N2-3 patients with positive pathologic specimens, the presence of these factors diminished recurrence-free survival (p = .01). The outcome of patients with pathologic carcinoma but without such ominous factors approached those with negative pathology.
Conclusions:
For patients with residual carcinoma in the neck following radiation, the pattern of residual disease is an effective predictor of recurrence.
