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Updated: Jun 29, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Erectile dysfunction in liver transplant patients.

E Huyghe¹, N Kamar, F Wagner

¹Department of Urology and Andrology, University Hospital, CHU Rangueil, Toulouse, France. huyghe.e@chu-toulouse.fr

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|October 16, 2008

Summary

Liver transplantation (LT) improves sexual activity, but erectile dysfunction (ED) persists in most men. Several factors, including cardiovascular disease and diabetes, are linked to ED post-transplant.

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Last Updated: Jun 29, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Area of Science:

Urology
Transplantation Medicine
Andrology

Background:

Liver transplantation (LT) is a life-saving procedure, but its impact on post-transplant sexual health, specifically erectile dysfunction (ED), requires further investigation.
Understanding the prevalence and risk factors for ED after LT is crucial for comprehensive patient care and improving quality of life.

Purpose of the Study:

To determine the frequency of erectile dysfunction (ED) in men following liver transplantation (LT).
To identify potential risk factors associated with ED and sexual dissatisfaction after LT.

Main Methods:

A questionnaire-based study involving 98 male liver transplant recipients (79.7% response rate) at a mean of 5.4 years post-transplant.
Erectile function assessed using the International Index for Erectile Function (IIEF) score; sexual satisfaction evaluated by the Treatment Satisfaction Status (TSS) score.
Analysis included patient perception of changes in sexual function over time and associations with various medical conditions and medications.

Main Results:

The proportion of sexually inactive men decreased post-LT (29% to 15%), indicating improved sexual activity.
However, the overall prevalence of erectile dysfunction (ED) remained unchanged after liver transplantation.
Key risk factors for ED included cardiovascular disease, post-transplant diabetes, alcohol abuse, and specific medications (antidepressants, ARBs).

Conclusions:

Liver transplantation (LT) positively impacts overall sexual activity but does not resolve pre-existing erectile dysfunction (ED) in most patients.
Erectile dysfunction (ED) post-LT is multifactorial, influenced by comorbidities like cardiovascular disease and diabetes, as well as certain pharmacological treatments.
Addressing ED requires a comprehensive approach considering patient history, comorbidities, and medication regimens to improve long-term sexual health outcomes.