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Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

Gilberto Paz-Filho1, Karin Esposito, Barry Hurwitz

  • 1Dept. of Psychiatry & Behavioral Sciences, Univ. of Miami Miller School of Medicine, Miami, FL 33136, USA.

American Journal of Physiology. Endocrinology and Metabolism
|October 16, 2008
PubMed
Summary

Leptin replacement therapy in deficient adults improves obesity and hypogonadism. Interrupting treatment decreased insulin resistance, suggesting high leptin levels may worsen obesity-related insulin resistance.

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