Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese
1Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Objective:
To investigate whether the ADRA2B D/I polymorphism is associated with anthropometric, metabolic, and blood pressure phenotypes in a Chinese population.
Methods:
In 1306 participants enrolled in the JingNing population study, we measured anthropometry, blood pressure, plasma glucose, and serum lipids, and genotyped the ADRA2B D/I polymorphism. We defined overweight (BMI >or= 25 kg/m2) and obesity (BMI >or= 30 kg/m2) according to the WHO criteria.
Results:
Genotype frequencies of the ADRA2B D/I polymorphism were significantly (P=0.02) different between 228 (17.5%) overweight and obese participants and 1078 normal weight participants, but similar between 317 (24.3%) hypertensive participants and 989 normotensive participants. After adjustment for covariates, the ADRA2B DD compared with II homozygotes had significantly (P
Conclusion:
The ADRA2B D allele is associated with a favourable anthropometric and metabolic profile in Chinese population, especially in physically less active participants.
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