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Updated: Jun 29, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
Published on: January 5, 2024
Symptoms accompanying fibromyalgia
1Dipartimento di Medicina Interna, Sezione di Reumatologia, Università degli Studi di Firenze, Firenze. m.zoppi@dmi.unifi.it
Spontaneous and provoked pain in fibromyalgia are unrelated. New symptoms like upper limb paresthesias, hemorrhoids, and epistaxis are common in fibromyalgia patients.
Area of Science:
- Rheumatology
- Pain Medicine
- Genetics
Background:
- Fibromyalgia is a complex chronic pain condition.
- Understanding the relationship between different pain types and associated symptoms is crucial for effective management.
Purpose of the Study:
- To investigate the relationship between spontaneous and provoked pain in fibromyalgia.
- To identify the frequency of associated symptoms, including those not typically linked to fibromyalgia.
Main Methods:
- Sixty-seven fibromyalgia patients were assessed.
- Spontaneous pain severity was measured using a visual analogue scale.
- Provoked pain was evaluated using a sensitive method assessing tender points and pain intensity, alongside symptom occurrence (paresthesias, hemorrhoids, epistaxis).
Main Results:
- No significant correlation was found between spontaneous and provoked pain severity.
- Headache, chronic fatigue, sleep disorders, irritable bowel syndrome, restless legs syndrome, upper limb paresthesias, hemorrhoids, and epistaxis were more frequent in fibromyalgia patients.
Conclusions:
- Spontaneous and provoked pain are independent clinical features of fibromyalgia.
- Upper limb paresthesias, hemorrhoids, and epistaxis are identified as typical fibromyalgia symptoms.
- These symptoms may stem from a connective tissue laxity diathesis, suggesting fibromyalgia could be a consequence.
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