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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Probability Laws01:49

Probability Laws

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.

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Phenotype analysis of families with TP53 germline variants at the Center for Familial Breast and Ovarian Cancer, Cologne.

Cancer medicine·2024
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Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
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Implementation and evaluation of a nurse-led decision-coaching program for healthy breast cancer susceptibility gene (BRCA1/2) mutation carriers: a study protocol for the randomized controlled EDCP-BRCA study.

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Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response-final results from GeparSixto.

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BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance.

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Related Experiment Video

Updated: Jun 29, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

[Hereditary breast cancer].

B Schlehe1, R Schmutzler

  • 1Universitätsfrauenklinik, Vossstrasse 9, 69115, Heidelberg. bettina.schlehe@med.uni-heidelberg.de

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|October 16, 2008
PubMed
Summary

Hereditary breast and ovarian cancer risk is significantly reduced by genetic testing and preventive strategies for BRCA1/2 mutation carriers. Early detection and targeted therapies like PARP inhibitors offer improved outcomes for high-risk individuals.

Area of Science:

  • Genetics
  • Oncology
  • Preventive Medicine

Context:

  • Hereditary breast and ovarian cancer (HBOC) accounts for 10% of all breast cancer cases.
  • Deleterious mutations in BRCA1 or BRCA2 genes confer a 60-80% lifetime risk for breast cancer and 20-40% for ovarian cancer.
  • An interdisciplinary approach involving 12 specialized German centers facilitates genetic testing and preventive options for high-risk families.

Purpose:

  • To summarize the established interdisciplinary approach for identifying high-risk families for genetic testing.
  • To highlight the efficacy of early detection methods and prophylactic surgeries in managing hereditary cancer risk.
  • To introduce novel therapeutic strategies, including PARP inhibitors, and ongoing research into other predisposing genes.

Summary:

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Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
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Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland

Published on: June 7, 2019

Related Experiment Videos

Last Updated: Jun 29, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
06:29

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland

Published on: June 7, 2019

  • Genetic mutations in BRCA1/2 significantly increase breast and ovarian cancer risk.
  • Early detection via imaging (ultrasound, mammography, MRI) and risk-reducing surgeries (prophylactic mastectomy, salpingo-oophorectomy) are effective.
  • New treatments targeting BRCA-deficient tumors (PARP inhibitors) and research into other genetic factors are advancing management.

    • Impact:

    • Improved early detection rates and reduced incidence of breast and ovarian cancers in high-risk populations.
    • Development of targeted therapies like PARP inhibitors for BRCA-mutated cancers.
    • Ongoing research to identify additional genetic predispositions in high-risk families, expanding the scope of genetic counseling and risk assessment.