Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The modified Hijdra scale for prediction of delayed cerebral infarcts after subarachnoid hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Blood-brain barrier opening as a predictor of epilepsy and mortality after subarachnoid haemorrhage.

EBioMedicine·2025
Same author

Total joint replacement with the stock Biomet system in adult hemifacial microsomia without glenoid fossa: a case report and literature review.

Maxillofacial plastic and reconstructive surgery·2025
Same author

Decreasing Bone Resorption by Inducing Anti-Osteoclastogenic IFN-γ and IL-10 Expression in the Spleen Through an Electromagnetic Field on LPS-Induced Osteoporosis Mice.

Bioengineering (Basel, Switzerland)·2025
Same author

Acceleration-Dependent Effects of Vibrotactile Gamma Stimulation on Cognitive Recovery and Cholinergic Function in a Scopolamine-Induced Neurotoxicity Mouse Model.

Biomedicines·2025
Same author

Physicochemical Modulation Strategies for Mass Production of Extracellular Vesicle.

Tissue engineering and regenerative medicine·2025

Related Experiment Video

Updated: Jun 29, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Extremely small-magnitude accelerations enhance bone regeneration: a preliminary study.

Soon Jung Hwang1, Svetlana Lublinsky, Young-Kwon Seo

  • 1Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, Seoul, South Korea.

Clinical Orthopaedics and Related Research
|October 16, 2008
PubMed
Summary

High-frequency, low-magnitude mechanical vibrations significantly accelerated bone regeneration in rat calvarial defects. This bone healing enhancement was observed in both scaffolded and non-scaffolded defects, suggesting a promising non-invasive therapeutic approach.

More Related Videos

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

Related Experiment Videos

Last Updated: Jun 29, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedics

Background:

  • Mechanical stimuli influence bone remodeling.
  • High-frequency, low-magnitude accelerations show anabolic and anticatabolic effects on bone.
  • Accelerating bone regeneration in critical-sized defects remains a challenge.

Purpose of the Study:

  • To investigate the efficacy of high-frequency, low-magnitude mechanical signals in enhancing calvarial bone regeneration.
  • To assess the impact of these signals on both scaffolded and non-scaffolded bone defects.
  • To determine the optimal parameters for mechanical stimulation in bone repair.

Main Methods:

  • Experimental rats with 5-mm bilateral calvarial defects were used (n=8).
  • Defects were either empty or contained a collagen scaffold.
  • Oscillatory accelerations (45 Hz, 0.4 g) were applied for 20 minutes daily for 3 weeks.
  • Bone regeneration was assessed 4 and 8 weeks post-surgery using imaging techniques.

Main Results:

  • Scaffolded defects receiving mechanical stimulation showed a 265% greater fractional bone area after 4 weeks compared to controls.
  • After 8 weeks, scaffolded defects exhibited increased area (181%), volume (137%), and thickness (53%) with stimulation.
  • Non-scaffolded defects demonstrated an 84% increase in bone volume and 33% increase in thickness following mechanical stimulation.

Conclusions:

  • Extremely low-level, high-frequency accelerations can significantly enhance osseous regenerative processes.
  • Mechanical stimulation is particularly effective in promoting bone regeneration within a supporting scaffold.
  • These findings suggest a potential non-invasive therapeutic strategy for accelerating bone healing.