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Updated: Jun 29, 2026

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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
An expeditious and environmentally friendly synthesis of 3-substituted isocoumarins using microwave irradiation
Khalid Mohammed Khan1, Sumbul Ahmed, Zulfiqar Ali Khan
1HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan. hassaan2@super.net.pk
Natural Product Research
|October 16, 2008
Abstract:
A microwave-assisted, environmentally friendly, high-yielding, time-saving synthesis of medicinally important 3-substituted isocoumarins was carried out in a single step by direct condensation of homophthalic acid with aryol and acyl chlorides under solvent-free conditions without any solid support. The synthesised isocoumarins were structurally characterised by microanalysis, 1H NMR, EI, IR and UV.

