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Updated: Jun 29, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

[Optical coherence tomography study in tamoxifen maculopathy].

M Baget-Bernaldiz¹, N Soler Lluis, P Romero-Aroca

¹Departamento de Oftalmología, Hospital de Sant Joan, Universitat i Virgili, Reus, España. mbaget@gmail.com

Archivos De La Sociedad Espanola De Oftalmologia

|October 16, 2008

Summary

Tamoxifen maculopathy can cause vision loss through retinal nerve fiber atrophy or macular edema. Advanced imaging techniques like fluorescein angiography and optical coherence tomography aid in diagnosis.

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Last Updated: Jun 29, 2026

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Area of Science:

Ophthalmology
Pharmacology

Background:

Tamoxifen is a widely used medication for breast cancer treatment.
Prolonged tamoxifen use can lead to ocular side effects, including maculopathy.

Observation:

A case report detailing a patient with progressive, bilateral vision loss after 13 years of tamoxifen treatment.
Ocular examination included fluorescein angiography and optical coherence tomography to assess macular changes.

Findings:

Tamoxifen maculopathy can manifest as retinal nerve fiber atrophy or macular edema.
Fluorescein angiography and optical coherence tomography provide complementary information for diagnosing tamoxifen-induced macular changes.

Implications:

Understanding the mechanisms of tamoxifen maculopathy is crucial for early detection and management.
Ophthalmologists should consider tamoxifen use in patients presenting with unexplained visual disturbances.