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Updated: Jun 29, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Detection of platinum dihydride bisphosphine complexes and studies of their reactivity through para-hydrogen-enhanced
Cyril Godard1, Joaquín López-Serrano, María-Dolores Gálvez-López
1Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
Abstract:
In-situ NMR studies on the reactions of Pt{CH2 = CHSi(Me)2}2O)(PCy3) with phosphines, HSiEt3 and--hydrogen or Pt(L)(L')(Me)(2) alone enable the detection of cis-Pt(L)(L')(H)2 [L = PCy3 and L' = PCy2H, PPh3 or PCy3] which then undergo hydride site interchange and H2 reductive elimination on the NMR timescale.
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