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Published on: February 26, 2013

Association between serum C-reactive protein elevation and atrial fibrillation after first anterior myocardial

Omer Gedikli1, Cihan Orem, Merih Baykan

  • 1Department of Cardiology, Black Sea Technical University, Trabzon, Turkey. omergedikli@yahoo.com

Clinical Cardiology
|October 16, 2008
PubMed

Insights

C-reactive protein (CRP) may be a risk factor for atrial fibrillation (AF) in patients recovering from acute myocardial infarction (MI). Higher CRP levels were independently associated with AF occurrence in this patient group.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Elevated inflammatory markers, including C-reactive protein (CRP), are linked to increased cardiac event risk in acute myocardial infarction (AMI) patients.
  • CRP's potential role in initiating atrial fibrillation (AF) has been hypothesized but not extensively studied in the context of AMI.

Purpose of the Study:

  • To investigate whether serum CRP levels are an independent risk factor for the development of AF in patients experiencing their first acute anterior wall MI.

Main Methods:

  • Prospective evaluation of 92 consecutive patients with first acute anterior wall MI.
  • Serum CRP levels measured on admission using ultrasensitive immunonephelometry.
  • Echocardiography for left ventricular (LV) dimensions and function assessment.
  • Continuous cardiac monitoring for AF detection in the coronary care unit.

Main Results:

  • Atrial fibrillation (AF) occurred in 20% of patients.
  • Univariate analysis revealed AF was associated with older age, higher CRP levels, larger LV end-systolic volume, higher LV ejection fraction, and larger left atrial diameter.
  • Multivariate analysis identified age and CRP levels as independent predictors of AF.

Conclusions:

  • Serum CRP levels may serve as a significant risk factor for developing AF in patients with acute anterior wall MI.
  • Findings suggest inflammation, as indicated by CRP, plays a role in AF pathogenesis post-MI.
Abstract

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