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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

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Published on: August 22, 2016

Novel hollow microcapsules based on iron-heparin complex multilayers.

Lu Yu¹, Yanguang Gao, Xiuli Yue

¹Nanomedicine and Biosensor Laboratory, Bio-X Center, Harbin Institute of Technology, Harbin 150080, China.

Langmuir : the ACS Journal of Surfaces and Colloids

|October 16, 2008

Summary

Novel iron-heparin hollow capsules were developed for injectable anticoagulation. These submicroscaled capsules offer prolonged anticoagulant activity compared to traditional heparin, showing potential for clinical use.

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Area of Science:

Biomaterials Science
Nanotechnology
Pharmacology

Background:

Iron-polysaccharide complexes are used for parenteral iron deficiency anemia treatment.
Heparin is a crucial anticoagulant, but its short duration limits its use.
Developing novel drug delivery systems for anticoagulants is essential.

Purpose of the Study:

To fabricate novel iron-heparin complexed hollow capsules.
To evaluate the anticoagulant properties and potential of these capsules as injectable vehicles.

Main Methods:

Alternating deposition of ferric ions (Fe3+) and heparin (Hep) onto polystyrene latex particles.
Fabrication of submicroscaled and microscaled hollow capsules via core dissolution.
Characterization using confocal microscopy and atomic force microscopy (AFM).
Assessment of anticoagulant activity using activated partial thromboplastin time (APTT) assay.

Main Results:

Spherical iron-heparin hollow capsules with nanoscaled wall thickness were successfully fabricated.
The complexation with Fe3+ did not compromise heparin's catalytic activity for antithrombin III-mediated thrombin inactivation.
The anticoagulant activity was 95.7 U/mg for (Fe3+/Hep)8 capsules.
Iron-heparin capsules demonstrated a more prolonged anticoagulant duration than heparin alone.

Conclusions:

Submicroscaled iron-heparin complexed hollow capsules are stable and retain anticoagulant efficacy.
These novel capsules show potential as injectable anticoagulant vehicles with extended duration.
Further research is warranted for clinical applications of these advanced biomaterials.