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In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers

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Published on: July 28, 2018

Shapes and self-movement in protocell systems.

Keisuke Suzuki¹, Takashi Ikegami

¹Department of General Systems Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. ksk@sacral.c.u-tokyo.ac.jp

Artificial Life

|October 16, 2008

Summary

This study explores how shapes influence self-movement using an extended autopoiesis model. Computer simulations reveal that membrane shapes dictate movement types, including observed chemotaxis in certain forms.

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Area of Science:

Theoretical Biology
Computational Biology
Systems Biology

Background:

Autopoiesis describes the self-boundary maintenance of living systems.
Understanding the link between physical form and autonomous movement is crucial in biology.
Previous models primarily focused on boundary maintenance, not motility emergence.

Purpose of the Study:

To investigate the influence of geometric shapes on self-movement within an autopoietic framework.
To examine the emergence of self-motility alongside autopoietic self-boundary generation.
To elucidate the mechanisms underlying shape-dependent movement, including chemotaxis.

Main Methods:

Development of an extended model of autopoiesis.
Conducting computer simulations to observe system behavior.
Analysis of internal chemical processes to understand observed phenomena.

Main Results:

Different membrane shapes lead to distinct types of self-movement.
Chemotaxis was observed in specific shapes, indicating directed movement.
Internal chemical dynamics correlate with observed self-motility and chemotaxis.

Conclusions:

Geometric shape is a critical factor in determining the self-movement capabilities of autopoietic systems.
The extended autopoiesis model successfully predicts emergent self-motility and chemotaxis.
Understanding internal chemical processes is key to explaining shape-driven motility.