Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolotheranostics of pancreatic cancer by targeting choline, glutamine, and glucose transporters with photoimmunotherapy.

Npj imaging·2026

Same author

Human epidermal growth factor receptor 3-targeted near-infrared photoimmunotherapy in a xenograft mouse model of breast cancer.

BMC cancer·2026

Same author

Epidermal growth factor receptor-targeted near-infrared photoimmunotherapy for malignant pleural mesothelioma.

Lung cancer (Amsterdam, Netherlands)·2026

Same author

Understanding tumor microenvironment dynamics and immune checkpoint inhibitor efficacy following mEGFR-targeted near-infrared photoimmunotherapy.

Cancer letters·2026

Same author

Near-infrared Photoimmunotherapy Targeting High-risk Human Neuroblastoma Cells Expressing GD2.

Anticancer research·2025

Same author

Enhancement of drug delivery through fibroblast activation protein-targeted near-infrared photoimmunotherapy.

JCI insight·2025

Search research articles

Related Experiment Video

Updated: Jun 29, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Dendrimer-based contrast agents for molecular imaging.

Michelle Longmire¹, Peter L Choyke, Hisataka Kobayashi

¹Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, USA.

Current Topics in Medicinal Chemistry

|October 16, 2008

Summary

Dendrimer-based contrast agents offer adaptable molecular imaging for organs. Chemical modifications optimize targeting, biodistribution, and payload release for enhanced imaging applications.

More Related Videos

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Related Experiment Videos

Last Updated: Jun 29, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Area of Science:

Nanotechnology
Molecular Imaging
Materials Science

Background:

Dendrimer-based contrast agents exhibit extensive adaptability for molecular imaging.
Atom-by-atom modification allows rational control over physical characteristics, biodistribution, and targeting.
Recent innovations enhance agent directibility and production efficiency.

Purpose of the Study:

To discuss advances in dendrimer-based contrast agents for molecular imaging.
To focus on chemical design strategies for various imaging modalities.
To highlight the development of multi-modality imaging agents.

Main Methods:

Review of chemical design principles for dendrimer-based contrast agents.
Exploration of modifications for optimizing physical properties and biodistribution.
Discussion of synthetic chemistry approaches for novel agent creation.

Main Results:

Dendrimer adaptability enables precise control over imaging agent characteristics.
Novel synthetic methods have led to efficient production and new agent types.
Multi-modality agents combining MRI, radionuclide, and fluorescence imaging have been developed.

Conclusions:

Dendrimer-based agents are highly adaptable for targeted molecular imaging.
Chemical design is crucial for optimizing agents across optical, MR, CT, and radionuclide imaging.
Advances facilitate the development of sophisticated multi-modality imaging solutions.