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Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3
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Therapeutic potential of Voltage gated Calcium channels

C Gopi Mohan1, Tamanna Gandhi

  • 1Centre for Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Punjab, India. cmohan@niper.ac.in

Mini Reviews in Medicinal Chemistry
|October 16, 2008
PubMed

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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