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Related Concept Videos

Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
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Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

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Sedatives and Hypnotics: Overview01:23

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Sleep-Wake Cycles01:24

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NREM Sleep
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Cognitive Learning01:21

Cognitive Learning

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REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

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Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
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Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

Sleep architecture, cocaine and visual learning.

Peter T Morgan1, Edward F Pace-Schott, Zakir H Sahul

  • 1Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA. peter.morgan@yale.edu

Addiction (Abingdon, England)
|October 16, 2008
PubMed
Summary
This summary is machine-generated.

Chronic cocaine users show impaired sleep-dependent learning during abstinence, linked to altered sleep architecture. Somno-tropic treatments may help mitigate these effects.

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Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
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Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
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Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Addiction Research

Background:

  • Chronic cocaine use disrupts sleep patterns, potentially causing cognitive deficits during abstinence.
  • Sleep disturbances may be a key factor in the cognitive dysfunction observed in abstinent cocaine users.

Purpose of the Study:

  • To investigate the relationship between sleep architecture changes and cognitive function during cocaine abstinence.
  • To determine if sleep disturbances contribute to cognitive impairments in chronic cocaine users.

Main Methods:

  • Polysomnography was used to measure rapid eye-movement (REM) sleep and slow-wave activity in 12 chronic cocaine users over 23 days.
  • Participants underwent randomized, placebo-controlled cocaine self-administration sessions.
  • Visual texture discrimination tasks assessed cognitive performance throughout the study.

Main Results:

  • REM sleep patterns changed with abstinence, initially rebounding then decreasing.
  • Overnight visual learning occurred after initial cocaine use but diminished with prolonged abstinence.
  • Slow-wave activity and REM sleep predicted overnight visual performance, similar to healthy individuals.

Conclusions:

  • Abstinence-related deficits in sleep-dependent learning are linked to altered sleep architecture in chronic cocaine users.
  • Sleep-focused ('somno-tropic') treatments could potentially alleviate the physiological consequences of cocaine abstinence.