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Malignancy and chronic wounds: Marjolin's ulcer
1Akron City Hospital, Ohio.
The Journal of Burn Care & Rehabilitation
|May 1, 1991
Summary
Squamous cell carcinoma can develop in chronic wounds, even those from old thermal injuries. This case required lower extremity amputations for disease eradication, highlighting the risks of malignant transformation in non-healing wounds.
Area of Science:
- Dermatology
- Oncology
- Wound Healing Research
Background:
- Malignancy can arise in chronic wounds from various causes.
- Chronic scars are a known site for malignant degeneration.
Observation:
- A rare case of bilateral lower extremity thermal injuries presented 40 years later as fungating wounds.
- Histologic examination confirmed squamous cell carcinoma in both wounds.
Findings:
- Surgical amputation of both lower extremities was necessary for complete cancer eradication.
- Reconstructive procedures were performed post-amputation.
Implications:
- This case underscores the potential for delayed malignant transformation in chronic burn scars.
- Understanding the mechanisms of malignant degeneration in chronic wounds is crucial for effective management.
- Early detection and treatment are vital for improving outcomes in such rare presentations.