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Localization of endogenous beta-galactoside-binding lectin as a means to distinguish malignant from benign skin
P Santa Lucia1, B D Wilson, H J Allen
1Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263.
The Journal of Dermatologic Surgery and Oncology
|August 1, 1991
Abstract:
The immunolocalization of a 30-kd endogenous lectin, referred to as galaptin, was studied in various skin tumor types. Basal cell carcinomas expressed little or no galaptin, whereas nonmalignant basaloid cells, squamous cell carcinomas, melanoma, nevi, and stroma showed more prominent galaptin immunostaining. Therefore, the immunodetection of galaptin may aid the dermatopathologist in difficult histologic diagnosis.