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Clear cell squamous cell carcinoma. A histologic, immunohistologic, and ultrastructural study
L Requena1, M Sánchez, I Requena
1Department of Dermatology, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
The Journal of Dermatologic Surgery and Oncology
|August 1, 1991
Summary
This study details a rare clear cell variant of squamous cell carcinoma (SCC). Microscopic analysis revealed clear cells with membrane-less cytoplasmic spaces, distinct from lipid vacuoles, necessitating careful differential diagnosis.
Area of Science:
- Pathology
- Oncology
- Histology
Background:
- Squamous cell carcinoma (SCC) typically presents a standard histopathologic appearance.
- Variations in SCC differentiation are common, but clear cell morphology is unusual.
Observation:
- A case of clear cell SCC was examined using light and electron microscopy.
- The clear cells exhibited an empty cytoplasm, negative for periodic acid-Schiff and alcian blue stains.
Findings:
- Electron microscopy showed cytoplasmic clear spaces lacking surrounding membranes.
- These features suggest the clear cells are not lipid vacuoles, differentiating them from other clear cell tumors.
Implications:
- Recognizing this uncommon SCC variant is crucial for accurate histopathologic diagnosis.
- Differential diagnosis must include other neoplasms with clear cell features.