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Direct effect of angiotensin II on in-vitro perfused rabbit ovary
T C Kuo1, K Endo, A M Dharmarajan
1Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Baltimore, MD 21205.
Journal of Reproduction and Fertility
|July 1, 1991
Abstract:
The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.