Related Experiment Video
Updated: Oct 21, 2026

Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes
Published on: January 3, 2020
[Enhancement of susceptibility of sulbactam/cefoperazone-treated bacteria to phagocytes]
T Tanaka1, K Iida-Tanaka, S Irino
11st Department of Internal Medicine, Kagawa Medical School.
Abstract:
Effects of sulbactam/cefoperazone (SBT/CPZ) on the host-parasite relationship were studied using an established mouse macrophage cell line. Since SBT inactivates some types of beta-lactamase strongly, a combination of SBT with CPZ shows marked antibacterial activities against the bacteria producing beta-lactamases. In addition, sub-MIC levels of SBT/CPZ made Escherichia coli more susceptible to bactericidal activity of macrophage. This study provides evidence that SBT/CPZ works in partnership with host defense mechanism against bacterial infections in clinical situations.
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