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Ventilatory response to sustained hypoxia during exercise.

D S Ward¹, T T Nguyen

¹Department of Anesthesiology, University of California Los Angeles, School of Medicine, 90024-1778.

Medicine and Science in Sports and Exercise

|June 1, 1991

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Exercise potentiates the body's response to hypoxia (low oxygen), increasing ventilation. However, exercise also prevents the typical decline in breathing during hypoxia by increasing respiratory rate.

Area of Science:

Physiology
Respiratory System
Exercise Physiology

Background:

Hypoxia stimulates breathing via carotid bodies, an effect amplified by exercise.
Hypoxia also has central nervous system depressant effects on breathing.
The interaction between exercise and hypoxic ventilatory depression is not well understood.

Purpose of the Study:

To investigate the ventilatory response to isocapnic hypoxia during rest and moderate exercise.
To determine if exercise alters the typical decline in ventilation observed during sustained hypoxia.

Main Methods:

Seven healthy adult males underwent 20-minute periods of isocapnic hypoxia (end-tidal O2 of 50 mm Hg).
These hypoxic periods were preceded and followed by isocapnic hyperoxia.

Related Experiment Videos

Ventilatory responses were measured at rest and during moderate exercise (45-75 W).

Main Results:

At rest, hypoxia initially increased ventilation, followed by a decline primarily due to reduced tidal volume.
During exercise, hypoxia caused a larger initial increase in ventilation.
Exercise abolished or significantly reduced the decline in ventilation during hypoxia, mainly by increasing respiratory frequency.

Conclusions:

Exercise potentiates the acute ventilatory response to hypoxia.
Exercise modifies breathing patterns (tidal volume and frequency) during hypoxia.
Exercise attenuates hypoxic ventilatory decline by increasing respiratory rate.