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Erythroid precursor fusion induced by Sendai virus.

M Djaldetti, H Bessler, P Fishman

Experimental Hematology

|January 1, 1977

Summary

Sendai virus (SV) causes significant changes in fetal mouse erythroid cells, including nuclear alterations and cell fusion. This virus can induce fusion between both dividing and non-dividing erythroid precursors.

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Area of Science:

Cell biology
Virology
Hematopoiesis

Background:

Sendai virus (SV) is known to induce cell fusion.
Erythroid precursors undergo specific maturation stages.

Purpose of the Study:

To describe the ultrastructural events of Sendai virus interaction with fetal mouse erythroid precursors.
To investigate SV-induced fusion of erythroid precursors at various maturation stages.

Main Methods:

Ultrastructural analysis of fetal mouse erythroid precursors infected with Sendai virus.

Main Results:

Sendai virus affects erythroid nuclei, causing nuclear membrane interruption and nucleolus enlargement.
SV induces fusion between erythroid precursors at different developmental stages.
SV-induced fusion occurs between both dividing and non-dividing erythroid precursor cells.

Conclusions:

Sendai virus significantly impacts erythroid precursor ultrastructure and promotes cell fusion across maturation stages.
The virus's interaction with erythroid cells provides insights into viral pathogenesis and cell fusion mechanisms.

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