The effect of Max Epa on low density lipoprotein metabolism: perspectives from an animal model

Rabbits were fed low fat cholesterol-free diets containing casein as the source of protein (27% w/w). One group of 6 animals was supplemented with fish oil (Max Epa; 0.5 ml oil/kg body weight) and compared with 6 animals which were supplemented with a mixture of corn, palm and soybean oils (1:1:1 v/v). VLDL triacylglycerol concentrations were lower in those supplemented with Max Epa. LDL cholesterol and the kinetics of LDL-apo B were unaffected. The results indicate that in endogenously hypercholesterolaemic animals with low triacyglycerol concentrations, casein and possibly other animal proteins, override any effect of this dose of fish oil on LDL metabolism.