Cytomegalovirus-associated gastric ulcer

Area of Science:

• Gastroenterology
• Virology
• Transplant Medicine

Background:

• Cytomegalovirus (CMV) post-transfusion syndrome is a known complication following blood transfusions.
• Upper gastrointestinal bleeding is a serious condition requiring prompt diagnosis and management.

Observation:

• A patient with CMV post-transfusion syndrome presented with upper gastrointestinal bleeding.
• A gastric ulcer was subsequently identified as the source of bleeding.
• The ulcer occurred in the context of CMV mononucleosis, prompting investigation for CMV involvement.

Findings:

• CMV was detected in gastroscopic biopsy specimens from the gastric ulcer.
• CMV was successfully cultured from the biopsy material, confirming active infection.
• These findings demonstrate the presence of CMV in the upper gastrointestinal tract.

Implications:

• This case highlights the importance of considering CMV as a cause of gastrointestinal complications in susceptible patients.
• Antemortem diagnosis of CMV-associated upper gastrointestinal disease is achievable.
• Early diagnosis facilitates timely and appropriate treatment, potentially improving patient outcomes.