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Updated: Jul 29, 2026
09:07
An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
Primary adenocarcinoma of bladder
T G Wilson1, T R Pritchett, G Lieskovsky
1Department of Urology, University of Southern California School of Medicine, Los Angeles.
Urology
|September 1, 1991
Summary
Radical cystectomy offers better outcomes for invasive bladder adenocarcinoma. Aggressive surgical treatment, including lymph node dissection and urinary diversion, is recommended for all patients regardless of cancer origin.
Area of Science:
- Urology
- Surgical Oncology
Background:
- Adenocarcinoma of the bladder is a rare bladder cancer.
- Urachal adenocarcinoma arises from the urachus, a remnant of the allantois.
- Nonurachal adenocarcinoma originates from the bladder epithelium.
Purpose of the Study:
- To compare treatment outcomes for urachal versus nonurachal bladder adenocarcinoma.
- To evaluate the efficacy of radical cystectomy in treating invasive bladder adenocarcinoma.
Main Methods:
- Retrospective analysis of 16 patients treated between 1983 and 1987.
- Patients with nonurachal adenocarcinoma underwent radical cystectomy, pelvic lymph node dissection, and urinary diversion.
- Patients with urachal adenocarcinoma were treated with either radical cystectomy or segmental cystectomy and urinary diversion.
Main Results:
- Three-year tumor-free survival rates were 48% for nonurachal and 31% for urachal adenocarcinoma.
- Patients undergoing radical cystectomy showed improved survival compared to those treated with segmental cystectomy for urachal tumors.
Conclusions:
- An aggressive surgical approach is advocated for invasive bladder adenocarcinoma.
- Radical cystectomy, bilateral pelvic lymph node dissection, and urinary diversion are recommended for all invasive bladder adenocarcinomas, irrespective of their origin.
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