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Related Experiment Videos

Functional asymmetries in the rodent barrel cortex.

J S McCasland1, G E Carvell, D J Simons

  • 1Division of Experimental Neurology and Neurosurgery Washington University School of Medicine, St. Louis, Missouri 63110.

Somatosensory & Motor Research
|January 1, 1991
PubMed
Summary

Rodent whisker barrel cortex shows functional asymmetries. Neurophysiological data aligns with metabolic 2-deoxyglucose (2DG) studies, confirming these organizational differences in rodent sensory processing.

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Area of Science:

  • Neuroscience
  • Sensory Systems
  • Cortical Organization

Background:

  • Neurophysiological and 2-deoxyglucose (2DG) studies reveal functional asymmetries in the rodent whisker barrel cortex.
  • Previous research suggests these metabolic activity gradients may stem from underlying electrophysiological differences in neural inhibition patterns.

Purpose of the Study:

  • To investigate if observed metabolic activity gradients in the barrel cortex correlate with electrophysiologically measured inhibitory asymmetries.
  • To compare 2-deoxyglucose (2DG) findings with predictions derived from single-cell receptive field data.

Main Methods:

  • Utilized 2-deoxyglucose (2DG) uptake measurements in behaving rodents.
  • Employed quantitative single-cell electrophysiology to gather receptive field data.

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  • Compared 2DG activity patterns with predictions based on neurophysiological measurements of neural inhibition.

    • Main Results:

    • 2DG activity distribution in the barrel cortex showed a decline from anteromedial to posterolateral regions, matching neurophysiological predictions.
    • The strength of neural inhibition in barrel neurons accurately predicted increased C3 barrel activation after adjacent whisker clipping.
    • Metabolic activity decrease during adjacent whisker stimulation was most pronounced in layer IV and least in infragranular layers, consistent with electrophysiological findings on inhibitory interactions.

    Conclusions:

    • Neurophysiological and metabolic studies provide congruent evidence for functional asymmetries in the rodent whisker barrel cortex.
    • Electrophysiologically determined surround and cross-whisker inhibition patterns explain the observed metabolic activity gradients.
    • The findings highlight the link between neural inhibition, laminar structure, and functional organization in the somatosensory cortex.