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Marker genotyping errors in old data on X-linkage in bipolar illness.
1Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892.
Biological Psychiatry
|April 1, 1991
Summary
Inconsistent results linking X-chromosome markers to bipolar disorder (BP) may stem from genotyping errors, not just genetic differences. This challenges previous X-linkage findings in BP illness.
Area of Science:
- Genetics
- Psychiatry
- Molecular Biology
Background:
- Previous studies reported inconsistent linkage between X-chromosome markers and bipolar disorder (BP).
- Genetic heterogeneity was proposed, but systematic procedural errors are also potential causes for these discrepancies.
Purpose of the Study:
- To re-evaluate the statistical evidence for X-linkage in bipolar disorder.
- To investigate potential systematic genotyping errors as a cause for inconsistent linkage findings.
Main Methods:
- Reanalysis of historical linkage data for bipolar illness from 1972-1975.
- Assessment of marker map consistency to detect potential genotyping errors.
Main Results:
- A reanalysis suggested spurious linkage between Xg and colorblindness markers in bipolar disorder studies.
- This apparent linkage is likely due to systematic genotyping errors, as the markers are distant on the X chromosome.
Conclusions:
- The support for X-linkage in bipolar disorder is diminished due to potential systematic genotyping errors.
- Inconsistencies in linkage studies may arise from both statistical and systematic factors, including procedural errors in genotyping.