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[Carbamazepine poisoning].

D Schläfke1, R Kloock

  • 1Klinik für Psychiatrie und Neurologie, Medizinische Fakultät, Universität Rostock.

Anaesthesiologie Und Reanimation
|January 1, 1991
PubMed
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Carbamazepine intoxication requires intensive care, including gastric lavage, activated charcoal, and forced diuresis. This case highlights the critical management of severe overdose symptoms and complications.

Area of Science:

  • Clinical Toxicology
  • Pharmacology

Background:

  • Increased use of carbamazepine necessitates awareness of potential intoxication risks.
  • Carbamazepine overdose can lead to severe neurological and cardiovascular complications.

Observation:

  • A 42-year-old patient ingested 50g of carbamazepine, resulting in a serum level of 118.74 mumol/l.
  • The patient experienced seizures, hypotension, electrolyte imbalances, and bronchopneumonia.
  • Management involved gastric lavage, activated charcoal, forced diuresis, hemodialysis, ventilation, and bronchoscopy.

Findings:

  • Despite severe overdose, the patient recovered consciousness on day 5 and was extubated on day 12.
  • Intensive supportive care was crucial for managing life-threatening complications.

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Implications:

  • There is no specific antidote for carbamazepine intoxication; management relies on supportive measures.
  • Recommendations include gastric lavage, repeated activated charcoal, osmotic diuretics, and forced diuresis.
  • Hemoperfusion is suggested for complicated coma cases.