Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffuse mesangial sclerosis in a fetus.

G S Spear1, K A Steinhaus, A Quddusi

  • 1Department of Pathology, California College of Medicine, University of California Irvine.

Clinical Nephrology
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The need for developing standardized family pedigree nomenclature.

Journal of genetic counseling·2013
Same author

Recommendations for standardized human pedigree nomenclature.

Journal of genetic counseling·2013
Same author

Postmortem DNA diagnosis of factor V Leiden in a neonate with systemic thrombosis and probable antithrombin deficiency.

Obstetrics and gynecology·1998
Same author

Diffuse renal cystic disease in children: morphologic and genetic correlations.

Pediatric nephrology (Berlin, Germany)·1998
Same author

Fas ligand gene transfer to renal allografts in rats: effects on allograft survival.

Transplantation·1998
Same author

Eosinophilic explant carditis with eosinophilia: ?Hypersensitivity to dobutamine infusion.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·1995
Same journal

Clinical characteristics and outcomes of adults with minimal change disease: A retrospective, cross-sectional study.

Clinical nephrology·2026
Same journal

Analysis of end-stage renal disease mediated by cuproptosis-related genes.

Clinical nephrology·2026
Same journal

The relationship between red cell distribution width and platelet ratio in acute kidney injury among ventilator-associated pneumonia patients: A MIMIC-IV database study.

Clinical nephrology·2026
Same journal

Arterial stiffness and choroidal vascularity index in autosomal dominant polycystic kidney disease with preserved kidney function.

Clinical nephrology·2026
Same journal

Antibody-drug conjugate therapy in a renal transplant patient with bladder cancer: A case report.

Clinical nephrology·2026
Same journal

Epigenetic age enhances eGFR-based prediction of all-cause mortality: A cross-cohort validation of a novel risk model.

Clinical nephrology·2026
See all related articles

This study reports the first case of fetal congenital nephrosis with diffuse mesangial sclerosis diagnosed before birth. This finding highlights a rare cause of nephrotic syndrome in fetuses, distinct from the Finnish type.

Area of Science:

  • Perinatal Medicine
  • Pediatric Nephrology
  • Fetal Pathology

Background:

  • Congenital nephrotic syndrome (CNS) is a rare kidney disorder presenting at birth.
  • The Finnish type is the most common form of CNS, characterized by specific genetic mutations.
  • Prenatal diagnosis of kidney abnormalities can be challenging, often relying on ultrasound findings.

Purpose of the Study:

  • To describe a unique case of antenatal diffuse mesangial sclerosis (DMS) presenting as fetal congenital nephrosis.
  • To highlight the pathological findings in a fetus diagnosed with a non-Finnish type of congenital nephrosis.
  • To report the first instance of fetal congenital nephrosis with prominent glomerular lesions.

Main Methods:

  • Pregnancy termination at 18 weeks gestation due to elevated maternal serum alpha-fetoprotein and ultrasound anomalies.

Related Experiment Videos

  • Ultrasound findings included severe oligohydramnios, intrauterine growth retardation, absent bladder, dolichocephaly, and possible hydrocephalus.
  • Post-termination pathological examination of the fetus, including histologic analysis of the kidneys.

    • Main Results:

    • Pathologic examination revealed diffuse mesangial sclerosis (DMS) in the fetal kidneys.
    • Histologic findings were consistent with the nephrotic syndrome.
    • This case represents the first reported instance of antenatal DMS and non-Finnish congenital nephrosis with significant glomerular pathology.

    Conclusions:

    • Diffuse mesangial sclerosis can manifest as congenital nephrosis in the fetus.
    • This case expands the spectrum of fetal kidney diseases and congenital nephrotic syndromes.
    • Antenatal diagnosis and understanding of fetal kidney pathology are crucial for genetic counseling and management.