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Updated: Aug 10, 2026

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
Published on: March 11, 2018
[Beta-glucuronidase activities assay in the ischemic brain in rats]
1Peking Union Medical College Hospital, Beijing.
Abstract:
Beta-glucuronidase (beta G) being a kind of hydrolases in the lysosome, the change of beta G activities has been known to be related to the degree of the damage of tissues or cells and the permeability of the cellular membranes. This study aimed at investigating beta G activities in rat brains and their changes after incomplete brain ischemia. It was shown that the brain beta G activities increased one hour, three hours and six hours after the rat brain ischemia was produced in the experimental rat models. Especially six hours after the rat brain ischemia was effected brain oedema became markedly evident.

