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[Changes in the endothelial cell density after perforating keratoplasty].

B Bergmann1, M Böhnke, R Winter

  • 1Universitäts-Augenklinik, Hamburg, Bundesrepublik Deutschland.

Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|January 1, 1991
PubMed
Summary

Endothelial cell density after penetrating keratoplasty shows a weak decline over time. Higher cell density was observed in younger donors and cultured corneas within the first year post-surgery.

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Area of Science:

  • Ophthalmology
  • Corneal Science
  • Cell Biology

Context:

  • Penetrating keratoplasty is a common corneal transplant procedure.
  • Endothelial cell density is a critical indicator of graft survival and visual function.
  • Long-term data on endothelial cell loss post-keratoplasty is essential for patient management.

Purpose:

  • To investigate the relationship between postoperative endothelial cell density and time since penetrating keratoplasty.
  • To compare endothelial cell density in different donor age groups and corneal treatments.
  • To establish normative data for endothelial cell density following corneal transplantation.

Summary:

  • A study of 590 endothelial photomicrographs from 327 patients undergoing penetrating keratoplasty (1981-1987) revealed a weak negative correlation (r = -0.39) between postoperative endothelial cell density and the postoperative period.

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  • Average endothelial cell density at 12-24 months was 1624 cells/mm², approximately 380 cells/mm² higher than reported in other studies.
  • Significantly higher cell densities were noted in cultured corneas and those from younger donors (≤39 years) up to one year postoperatively, with no significant differences across diagnosis groups.

    • Impact:

    • Provides valuable insights into the natural course of endothelial cell loss after penetrating keratoplasty.
    • Suggests potential benefits of using younger donor corneas and cultured corneas for improved graft longevity.
    • Contributes to a better understanding of factors influencing corneal graft survival and informs clinical practice for corneal transplantation.