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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Screening healthy people for diabetes: is it worthwhile?
1Department of Community Medicine, Memorial University of Newfoundland, Gloverton, Canada.
The Journal of Family Practice
|August 1, 1991
Summary
Routine screening for diabetes mellitus in healthy adults over 40 is not recommended. Focus screening efforts on high-risk individuals to efficiently detect unknown diabetes cases.
Area of Science:
- Endocrinology
- Public Health
- Epidemiology
Background:
- Estimating the prevalence of undiagnosed diabetes mellitus in healthy adults aged 40 and older.
- Determining the ratio of known to unknown diabetes cases.
- Calculating the true prevalence of diabetes in the target population.
Purpose of the Study:
- To estimate the prevalence of previously undiagnosed diabetes mellitus in a healthy population aged 40 years and older.
- To determine the ratio of known to unknown diabetics.
- To estimate the true prevalence of diabetes based on the findings.
Main Methods:
- A random sample of 1 in 5 healthy patients aged 40+ from rural family physician offices were tested for fasting plasma glucose (FPG).
- Elevated FPG levels (≥7.8 mmol/L) triggered a confirmatory second FPG test on a subsequent day.
- Reflectance glucometers were utilized for FPG level testing.
Main Results:
- The study identified one new diabetes case for every 15 known cases, indicating a 0.7% prevalence of unknown diabetes.
- The estimated prevalence of diabetes in the 40+ population increased from 11.0% to 11.7%.
- Overall population diabetes prevalence estimates rose slightly from 4.4% to 4.6%.
Conclusions:
- Routine diabetes mellitus screening in asymptomatic individuals aged 40 and older is not cost-effective.
- Diabetes screening should be prioritized and targeted towards specific high-risk patient groups.
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