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[Skeletal alterations associated with long-term etretinate therapy].

N Okada1, M Higashiyama, S Morimoto

  • 1Department of Dermatology, Osaka University School of Medicine.

Nihon Hifuka Gakkai Zasshi. the Japanese Journal of Dermatology
|April 1, 1991
PubMed
Summary

Long-term etretinate therapy for skin conditions like psoriasis can lead to skeletal changes such as hyperostosis and ligament calcification. Regular skeletal examinations are recommended for patients undergoing this treatment.

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Area of Science:

  • Dermatology
  • Radiology
  • Rheumatology

Background:

  • Etretinate is a retinoid used to treat keratinizing disorders.
  • Long-term use of retinoids can have various side effects.
  • Skeletal toxicity of etretinate requires further investigation.

Purpose of the Study:

  • To evaluate the prevalence and degree of skeletal alterations in patients treated with etretinate.
  • To compare skeletal findings in etretinate-treated patients with controls.
  • To assess the clinical and laboratory correlates of etretinate-induced skeletal changes.

Main Methods:

  • Radiographic skeletal examinations were conducted on 16 adult patients.
  • Patients had received etretinate for psoriasis vulgaris, pustular psoriasis, or pustulosis palmoplantaris.

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  • Findings were compared to age- and sex-matched, untreated controls.

    • Main Results:

    • Increased frequency and degree of skeletal alterations, including hyperostosis, ligament calcification, and periosteal thickening, were observed in etretinate-treated patients.
    • These skeletal changes were found more often and were more severe than in controls.
    • Most patients were asymptomatic with normal laboratory findings (serum calcium, phosphate, alkaline phosphatase).

    Conclusions:

    • Long-term etretinate therapy is associated with significant skeletal abnormalities.
    • Skeletal changes may occur even in asymptomatic patients with normal laboratory values.
    • Regular radiographic skeletal examinations are necessary for patients on long-term etretinate therapy to monitor for these abnormalities.