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Updated: Jul 31, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
Published on: January 19, 2017
Medium reiteration frequency repetitive sequences in the human genome
D J Kaplan1, J Jurka, J F Solus
1Center for Molecular Biology, Wayne State University, Detroit, MI.
Researchers identified fourteen new medium reiteration frequency (MER) families in the human genome. These families, along with six known ones, range from 200 to 10,000 copies per haploid genome.
Area of Science:
- Genomics
- Molecular Biology
- Human Genetics
Background:
- The human genome contains repetitive DNA sequences.
- Medium reiteration frequency (MER) elements are a class of repetitive DNA.
Purpose of the Study:
- To identify novel MER families in the human genome.
- To estimate the copy number of MER families.
Main Methods:
- Utilized two distinct bioinformatic methods for MER family identification.
- Quantified repetition frequencies per haploid human genome for identified MER families.
Main Results:
- Discovered fourteen novel MER families.
- Estimated copy numbers for both novel and previously described MER families.
- MER families exhibit copy number variation from 200 to 10,000 elements per haploid genome.
Conclusions:
- The human genome harbors a significant number of diverse MER elements.
- Copy number variation is a characteristic feature of MER families.
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